Journal
BRITISH JOURNAL OF PSYCHIATRY
Volume 193, Issue 3, Pages 216-221Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1192/bjp.bp.107.048314
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Funding
- Medical Research Council
- Wellcome Trust [076274/Z/04/Z]
- National institute of Biomedical Imaging Bioengineering
- National Institute of Mental Health, USA
- Harnett Fund, University of Cambridge
- Medical Research Council [G0001354B, G0001354] Funding Source: researchfish
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Background Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking. Aims To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania. Method Eighteen patients with DSM-IV trichotillomania and 19 healthy controls undertook structural magnetic resonance imaging after providing written informed consent. Differences in grey and white matter were investigated using computational morphometry. Results Patients with trichotillomania showed increased grey matter densities in the left striatum, left amygdalo-hippocampal formation, and multiple (including cingulate, supplementary motor, and frontal) cortical regions bilaterally. Conclusions Trichotillomania was associated with structural grey matter changes in neural circuitry implicated in habit learning, cognition and affect regulation. These findings inform animal models of the disorder and highlight key regions of interest for future translational research.
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