Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 172, Issue 8, Pages 2101-2113Publisher
WILEY
DOI: 10.1111/bph.12901
Keywords
-
Categories
Funding
- UK Department of Health through the National Institute for Health Research Biomedical Research Centre
- Medical Research Council [MR/J007501/1]
- British Heart Foundation [SP/14/2/30922] Funding Source: researchfish
- Medical Research Council [MR/J007501/1, G0802033, G1001138] Funding Source: researchfish
- MRC [MR/J007501/1, G0802033, G1001138] Funding Source: UKRI
Ask authors/readers for more resources
PKs transfer a phosphate from ATP to the side-chain hydroxyl group of a serine, threonine or tyrosine residue of a substrate protein. This in turn can alter that protein's function; modulating fundamental cellular processes including, metabolism, transcription, growth, division, differentiation, motility and survival. PKs are subdivided into families based on homology. One such group are the stress-activated kinases, which as the name suggests, are activated in response to cellular stresses such as toxins, cytokines, mechanical deformation and osmotic stress. Members include the p38 MAPK family, which is composed of , , and , isoforms which are encoded by separate genes. These kinases transduce extracellular signals and coordinate the cellular responses needed for adaptation and survival. However, in cardiovascular and other disease states, these same systems can trigger maladaptive responses that aggravate, rather than alleviate, the disease. This situation is analogous to adrenergic, angiotensin and aldosterone signalling in heart failure, where inhibition is beneficial despite the importance of these hormones to homeostasis. The question is whether similar benefits could accrue from p38 inhibition? In this review, we will discuss the structure and function of p38, the history of p38 inhibitors and their use in preclinical studies. Finally, we will summarize the results of recent cardiovascular clinical trials with p38 inhibitors. Linked ArticlesThis article is part of a themed section on Conditioning the Heart - Pathways to Translation. To view the other articles in this section visit
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available