Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 171, Issue 15, Pages 3595-3603Publisher
WILEY-BLACKWELL
DOI: 10.1111/bph.12713
Keywords
-
Categories
Funding
- Hong Kong Research Grant Council [CUHK464712]
- National Basic Research Program of China [2012CB517805]
- CUHK Focused Investment Scheme B
Ask authors/readers for more resources
IL-6 is a pleiotropic cytokine that participates in normal functions of the immune system, haematopoiesis, metabolism, as well as in the pathogenesis of metabolic and cardiovascular diseases. Both pro- and anti-inflammatory roles of IL-6 have been described, which are distinguished by different cascades of signalling transduction, namely classic and trans-signalling. The present review summarizes the basic principles of IL-6 signalling and discusses its roles in diabetes and associated cardiovascular complications, with emphasis on the different outcomes mediated by the two modes of IL-6 signalling and the value of developing therapeutic strategies to specifically target the deleterious trans-signalling of IL-6.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available