Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 171, Issue 10, Pages 2568-2581Publisher
WILEY
DOI: 10.1111/bph.12569
Keywords
transient receptor potential (TRP) channels; skin; barrier; differentiation; inflammation; atopic dermatitis
Categories
Funding
- Hungarian research grants ('Lendulet') [LP003/2011, OTKA 101761]
- European Union under REA Grant [330489]
- European Union
- State of Hungary
- European Social Fund [TAMOP 4.2.4. A/2-11-1-2012-0001]
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Emerging evidence suggests that transient receptor potential (TRP) ion channels not only act as polymodal cellular sensors' on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they appear to be critically involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of the skin barrier, skin cell proliferation and differentiation, and immune functions. Moreover, we also describe the putative involvement of several TRP channels in the development of certain skin diseases and identify future TRP channel-targeted therapeutic opportunities. Linked ArticlesThis article is part of a themed section on the pharmacology of TRP channels. To view the other articles in this section visit
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