Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 171, Issue 1, Pages 12-23Publisher
WILEY
DOI: 10.1111/bph.12407
Keywords
ATP-sensitive potassium channel; cardiac myocyte; smooth muscle; physiology; pathophysiology
Categories
Funding
- British Heart Foundation
- Wellcome Trust
- Medical Research Council
- National Institute for Health Research Barts Cardiovascular Biomedical Research
- British Heart Foundation [RG/10/10/28447] Funding Source: researchfish
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ATP-sensitive potassium channels (K-ATP) are widely distributed and present in a number of tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels. Thus, they link cellular metabolism with membrane excitability. Recent studies using genetically modified mice and genomic studies in patients have implicated K-ATP channels in a number of physiological and pathological processes. In this review, we focus on their role in cellular function and protection particularly in the cardiovascular system.
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