Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 171, Issue 2, Pages 332-350Publisher
WILEY
DOI: 10.1111/bph.12415
Keywords
sleep; arousal; narcolepsy; hypothalamus; addiction; anxiety; stress; neuropeptide
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The hypocretins (Hcrts), also known as orexins, are two peptides derived from a single precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin system has been associated with numerous physiological functions, including sleep/arousal, energy homeostasis, endocrine, visceral functions and pathological states, such as narcolepsy and drug abuse. Here, we review the discovery of Hcrt/orexins and their receptors and propose a hypothesis as to how the orexin system orchestrates these multifaceted physiological functions. Linked ArticlesThis article is part of a themed section on Orexin Receptors. To view the other articles in this section visit
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