Related references
Note: Only part of the references are listed.An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment
M. R. Davies et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG
Malin K. B. Jonsson et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)
Circadian rhythms govern cardiac repolarization and arrhythmogenesis
Darwin Jeyaraj et al.
NATURE (2012)
Is it time for in silico simulation of drug cardiac side effects?
Gary R. Mirams et al.
ANIMAL MODELS: THEIR VALUE IN PREDICTING DRUG EFFICACY AND TOXICITY (2011)
On the relationship between block of the cardiac Na+ channel and drug-induced prolongation of the QRS complex
A. R. Harmer et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
Gary R. Mirams et al.
CARDIOVASCULAR RESEARCH (2011)
Novel Approaches to Assessing Cardiac Safety – Proceedings of a Workshop
Katherine Fletcher et al.
DRUG SAFETY (2011)
Counterpoint: M cells do not have a functional role in the ventricular myocardium of the intact heart
Michiel J. Janse et al.
HEART RHYTHM (2011)
Point: M cells are present in the ventricular myocardium
Lance D. Wilson et al.
HEART RHYTHM (2011)
Resolving the M-cell debate: Why and how
Stanley Nattel et al.
HEART RHYTHM (2011)
Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis
Amrita X. Sarkar et al.
HEART RHYTHM (2011)
A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity
Cristian Obiol-Pardo et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
DeltaT50—a new method to assess temporal ventricular repolarization variability
Christina Abrahamsson et al.
JOURNAL OF ELECTROCARDIOLOGY (2011)
Shaping a new Ca2+ conductance to suppress early afterdepolarizations in cardiac myocytes
Roshni V. Madhvani et al.
JOURNAL OF PHYSIOLOGY-LONDON (2011)
Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
Piet H. van der Graaf et al.
PHARMACEUTICAL RESEARCH (2011)
An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation
Gary Gintant
PHARMACOLOGY & THERAPEUTICS (2011)
Verification of cardiac tissue electrophysiology simulators using an N-version benchmark
Steven A. Niederer et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2011)
High-throughput functional curation of cellular electrophysiology models
Jonathan Cooper et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)
Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing
T. A. Quinn et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)
A Computational Model to Predict the Effects of Class I Anti-Arrhythmic Drugs on Ventricular Rhythms
Jonathan D. Moreno et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Ventricular rate adaptation: A novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds
Jonathon R. Green et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2011)
Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit
Ingemar Jacobson et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2011)
Simulating human cardiac electrophysiology on clinical time-scales
Steven Niederer et al.
FRONTIERS IN PHYSIOLOGY (2011)
The open-access dataset for insilico cardiotoxicity prediction system
Sebastian Polak et al.
BIOINFORMATION (2011)
Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue
Karen Cardona et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)
Pharmacodynamic Effects in the Cardiovascular System: The Modeller's View
Martin Fink et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2010)
An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk
C. E. Pollard et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
The Systems Biology Approach to Drug Development: Application to Toxicity Assessment of Cardiac Drugs
B. Rodriguez et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)
Systems Biology: An Approach
P. Kohl et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)
Multi-scale electrophysiology modeling: from atom to organ
Jonathan R. Silva et al.
JOURNAL OF GENERAL PHYSIOLOGY (2010)
A novel computational model of the human ventricular action potential and Ca transient
Eleonora Grandi et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
Karl Swedberg et al.
LANCET (2010)
Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations
A. Corrias et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2010)
A vision and strategy for the virtual physiological human in 2010 and beyond
Peter Hunter et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2010)
Chaste: A test-driven approach to software development for biological modelling
Joe Pitt-Francis et al.
COMPUTER PHYSICS COMMUNICATIONS (2009)
Modeling and Simulation of Preclinical Cardiac Safety: Towards an Integrative Framework
Antoine Soubret et al.
DRUG METABOLISM AND PHARMACOKINETICS (2009)
Multiscale modelling of drug-induced effects on cardiac electrophysiological activity
T. Brennan et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
Systems biology and the virtual physiological human
Peter Kohl et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
CELLULAR OPEN RESOURCE (COR): current status and future directions
Alan Garny et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2009)
Simulation of cardiac electrophysiology on next-generation high-performance computers
Rafel Bordas et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2009)
Markov models for ion channels: versatility versus identifiability and speed
Martin Fink et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2009)
A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential
Jonathan R. Silva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers:: insights from mathematical models and experimental correlates
Philippe Comtois et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)
The CellML model repository
Catherine M. Lloyd et al.
BIOINFORMATICS (2008)
Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective
C. E. Pollard et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
New Antiarrhythmic Drugs for the Treatment of Atrial Fibrillation
Joern Schmitt et al.
HERZ (2008)
Computational models of the heart and their use in assessing the actions of drugs
Denis Noble
JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)
In Silico Prediction of the Chemical Block of Human Ether-a-Go-Go-Related Gene (hERG) K+ Current
Atsushi Inanobe et al.
JOURNAL OF PHYSIOLOGICAL SCIENCES (2008)
Minimal model for human ventricular action potentials in tissue
Alfonso Bueno-Orovio et al.
JOURNAL OF THEORETICAL BIOLOGY (2008)
The canine virtual ventricular wall: A platform for dissecting pharmacological effects on propagation and arrhythmogenesis
Alan P. Benson et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2008)
Modelling the molecular basis of cardiac repolarization
Yoram Rudy
EUROPACE (2007)
Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model
Kenji Tsujimae et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Effects of early afterdepolarizations on reentry in cardiac tissue: a simulation study
Ray B. Huffaker et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation
Colleen E. Clancy et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Alternans and spiral breakup in a human ventricular tissue model
K. H. W. J. ten Tusscher et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)
Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine
L. Belardinelli et al.
HEART (2006)
Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload
D Noble et al.
HEART (2006)
Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart
D Bottino et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2006)
Simulated interactions between a class III antiarrhythmic drug and a figure 8 reentry
RG Seigneuric et al.
ACTA BIOTHEORETICA (2005)
Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death
SMJM Straus et al.
EUROPEAN HEART JOURNAL (2005)
Effects of Na+ and K+ channel blockade on vulnerability to and termination of fibrillation in simulated normal cardiac tissue
ZL Qu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2005)
Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia:: A simulation study
B Trénor et al.
ANNALS OF BIOMEDICAL ENGINEERING (2005)
Pentamidine reduces hERG expression to prolong the QT interval
JS Cordes et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
QT prolongation through hERG K+ channel blockade:: Current knowledge and strategies for the early prediction during drug development
M Recanatini et al.
MEDICINAL RESEARCH REVIEWS (2005)
Dimensionality in cardiac modelling
A Garny et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2005)
Structural and functional characterisation of cardiac fibroblasts
P Camelliti et al.
CARDIOVASCULAR RESEARCH (2005)
Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells
M Pásek et al.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING (2004)
The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: Influence of multi-channel block
RL Martin et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2004)
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
C Antzelevitch et al.
CIRCULATION (2004)
Mechano-electric interactions in heterogeneous myocardium: development of fundamental experimental and theoretical models
VS Markhasin et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2003)
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
WS Redfern et al.
CARDIOVASCULAR RESEARCH (2003)
Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: Importance of triangulation, reverse use dependence, and instability
LM Hondeghem et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2003)
The rise of computational biology
D Noble
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Na+ channel mutation that causes both Brugada and long-QT syndrome phenotypes -: A simulation study of mechanism
CE Clancy et al.
CIRCULATION (2002)
HERG K+ channels: friend and foe
JI Vandenberg et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2001)
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death
CE Clancy et al.
CARDIOVASCULAR RESEARCH (2001)
Share Paper
