Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 165, Issue 3, Pages 683-692Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1476-5381.2011.01568.x
Keywords
17(R)-resolvin D1; TRPV3; specific inhibitor; pain; keratinocytes; nociceptive behaviours; inflammation
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Funding
- Korea Research Foundation, Republic of Korea [KRF-2008-331-E00457, 2009-0076543]
- National Research Foundation of Korea [2008-331-E00457, 2009-0076543, 331-2008-1-E00457] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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BACKGROUND AND PURPOSE Transient receptor potential ion channel vanilloid 3 (TRPV3) is expressed in skin keratinocytes and plays an important role in thermal and chemical nociceptions in the periphery. The presence of TRPV3 inhibitors would improve our understanding of TRPV3 function and help to develop receptor-specific analgesics. However, little is known about physiological substances that specifically inhibit TRPV3 activity. Here, we investigated whether 17(R)-resolvin D1 (17R-RvD1), a naturally occurring pro-resolving lipid specifically affects TRPV3 activity.
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