Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 164, Issue 8, Pages 1929-1938Publisher
WILEY
DOI: 10.1111/j.1476-5381.2011.01481.x
Keywords
Acetyl salicylic acid; bile acids; cystathionine-?- lyase; farnesoid X receptor; hydrogen sulphide; nitric oxide; non-steroidal anti-inflammatory drugs; nuclear receptors
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BACKGROUND AND PURPOSE Low doses of acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage. The farnesoid X receptor (FXR) is a bile acid sensor essential for maintenance of intestinal homeostasis. Here, we have investigated whether FXR is required for mucosal protection in models of gastrointestinal injury caused by ASA and NSAIDs and if FXR activation has potential in the treatment or prevention of gastrointestinal injury caused by these agents.
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