Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 164, Issue 8, Pages 2042-2053Publisher
WILEY
DOI: 10.1111/j.1476-5381.2011.01518.x
Keywords
salvianolic acid B; dendritic cell; PPAR; TLR4; atherosclerosis
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Funding
- National Basic Research Program of China [2011CB503905]
- Science and Technology Ministry [2006AA0ZA406]
- National Natural Science Foundation of China [30725036]
- Key Projects in the National Science & Technology Pillar Program in the Eleventh Five-year Plan Period [2006BAI01A04]
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BACKGROUND AND PURPOSE Salvianolic acid B (Sal B), a water-soluble antioxidant derived from a Chinese medicinal herb, is known to be effective in the prevention of atherosclerosis. Here, we tested the hypothesis that the anti-atherosclerotic effect of Sal B might be mediated by suppressing maturation of human monocyte-derived dendritic cells (h-monDC).
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