Journal
JOURNAL OF CONTROLLED RELEASE
Volume 219, Issue -, Pages 43-60Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2015.09.038
Keywords
Nanomedicine; Alternating magnetic field; Magnetic nanoparticles; Magneto-mechanical actuation
Funding
- Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the United States National Institutes of Health [P20GM103480]
- UNC Eshelman School of Pharmacy
- University Cancer Research Fund through the UNC Lineberger Comprehensive Cancer Center
- Carolina Center of Cancer Nanotechnology Excellence
- Ministry of Education and Science of the Russian Federation [11.G34.31.004, K1-2014-022]
- Russian Science Foundation [RSF-14-13-00731, RSF-15-19-00181]
- Russian Science Foundation [14-13-00731, 15-19-00181] Funding Source: Russian Science Foundation
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The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia. (C) 2015 Elsevier B.V. All rights reserved.
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