Journal
JOURNAL OF CONTROLLED RELEASE
Volume 219, Issue -, Pages 445-456Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2015.09.017
Keywords
Nucleic acids; Dermal drug delivery; Skin disease
Funding
- Duncan and Suzanne Mellichamp
- National Institutes of health [1R21CA191133]
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Nucleic acids (NAs) hold significant potential for the treatment of several diseases. Topical delivery of NAs for the treatment of skin diseases is especially advantageous since it bypasses the challenges associated with systemic administration which suffers from enzymatic degradation, systemic toxicity and lack of targeting to skin. However, the skin's protective barrier function limits the delivery of NAs into skin after topical application. Here, we highlight strategies for enhancing delivery of NAs into skin, and provide evidence that translation of topical NA therapies could have a transformative impact on the treatment of skin diseases. (C) 2015 Elsevier B.V. All rights reserved.
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