Journal
JOURNAL OF CONTROLLED RELEASE
Volume 219, Issue -, Pages 416-430Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2015.09.037
Keywords
Silk; Stabilization; Recovery; Biologics; Mechanisms; Processing; Interactions
Funding
- National Institute of Health [P41 EB002520]
- Air Force Office of Scientific Research [FA9550-14-1-0015]
- Defense Threat Reduction Agency [HDTRA1-14-1-0061]
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Silk fibroin is a high molecular weight amphiphilic protein that self-assembles into robust biomaterials with remarkable properties including stabilization of biologicals and tunable release kinetics correlated to processing conditions. Cells, antibiotics, monoclonal antibodies and peptides, among other biologics, have been encapsulated in silk using various processing approaches and material formats. The mechanistic basis for the entrapment and stabilization features, along with insights into the modulation of release of the entrained compounds from silks will be reviewed with a focus on stabilization of bioactive molecules. (C) 2015 Elsevier B.V. All rights reserved.
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