Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 157, Issue 2, Pages 153-165Publisher
WILEY
DOI: 10.1038/bjp.2008.349
Keywords
viral vectors; gene therapy; AAV; Ad; HSV; lentivectors; pseudotyping; cell targeting; transcriptional targeting; vectors production
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Funding
- INSERM, ENS Lyon
- Ligue Nationale Contre le Cancer, the European Community [LSHB-CT-2004-005242]
- Agence Nationale de Recherches sur le SIDA et les HEpatites Virales (ANRS)
- Association Francaise contre les Myopathies (AFM)
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In the late 1970s, it was predicted that gene therapy would be applied to humans within a decade. However, despite some success, gene therapy has still not become a routine practise in medicine. In this review, we will examine the problems, both experimental and clinical, associated with the use of viral material for transgenic insertion. We shall also discuss the development of viral vectors involving the most important vector types derived from retroviruses, adenoviruses, herpes simplex viruses and adeno-associated viruses.
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