Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 146, Issue 8, Pages 1041-1059Publisher
WILEY
DOI: 10.1038/sj.bjp.0706416
Keywords
neurodegeneration; protein aggregation; oxidative stress; A beta-amyloid; alpha-synuclein; prion protein; chelation therapy; iron; copper
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The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review, Alzheimer's disease, Parkinson's disease and prion disease are discussed, with the aim of identifying common trends underlying these devastating neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.
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