Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 153, Issue -, Pages S396-S405Publisher
WILEY
DOI: 10.1038/sj.bjp.0707626
Keywords
cerebral ischaemia; cerebral haemorrhage; neuroprotection; blood-brain barrier; animal models; clinical trials
Categories
Funding
- NINDS NIH HHS [R01 NS053560, R01 NS037074, R01-NS37074, R01-NS48422, P50-NS10828, R01 NS048422, P01-NS55104, R01-NS53560, P01 NS055104, P50 NS010828, R01 NS056458, R01-NS56458] Funding Source: Medline
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Numerous failures in clinical stroke trials have led to some pessimism in the field. This short review examines the following questions: Can experimental models of stroke be validated? How can combination stroke therapies be productively pursued? Can we achieve neuroprotection without reperfusion? And finally, can we move from a pure neurobiology view of stroke towards a more integrative approach targeting all cell types within the entire neurovascular unit? Emerging data from both experimental models and clinical findings suggest that neurovascular mechanisms may provide new opportunities for treating stroke. Ultimately, both bench-to-bedside and bedside-back-to-bench interactions may be required to overcome the translational hurdles for this challenging disease.
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