Journal
JOURNAL OF CONTROLLED RELEASE
Volume 206, Issue -, Pages 1-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2015.03.006
Keywords
Oral films; Film forming polymers; Market; Galenical development
Funding
- FCT grant [SFRH/BDE/51271/2010]
- QREN SI-I&DT Empresa Individual Project [18472]
- Fundação para a Ciência e a Tecnologia [SFRH/BDE/51271/2010] Funding Source: FCT
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Polymers are the most common excipients used in pharmaceutical dosage forms, and often new applications and innovative polymers appear aiming to overcome unmet needs in the drug formulation field. Orodispersible dosage forms based on polymeric matrices have currently demonstrated their prominence in accordance with the actual market requirements and patients' demands. The versatility of the polymeric oral films had proven their high value as suitable technological platforms for extension and adjustment to different delivery routes and promising markets. These are the main reasons for the increasing investment of several companies in this technology and their applicability in different therapeutic segments. This pharmaceutical form with a blustering beginning as a breath freshener had an emergent entrance in the Rx market proving its reliable value. This review describes and explores the oral film technology from its main component, the polymeric matrices, to the new and possible market applications, highlighting all the critical and important points of its development. (C) 2015 Elsevier B.V. All rights reserved.
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