Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 147, Issue -, Pages S27-S37Publisher
WILEY
DOI: 10.1038/sj.bjp.0706455
Keywords
G-protein-coupled receptors; historical perspective; British Pharmacological Society 75th Anniversary; ligand binding; function; dimerization; cell signalling; desensitization
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Funding
- Biotechnology and Biological Sciences Research Council [BB/C507853/1, BB/D521581/1] Funding Source: Medline
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The G-protein-coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have therapeutic actions across a wide range of human diseases ranging from allergic rhinitis to pain, hypertension and schizophrenia. This review provides a brief historical overview of the properties and signalling characteristics of this important family of receptors.
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