Journal
JOURNAL OF CONTROLLED RELEASE
Volume 205, Issue -, Pages 190-205Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2015.02.007
Keywords
Nanoparticle; Nitric oxide; Gasotransmitter; Therapy
Funding
- Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology [CE140100036]
- Australian Laureate Fellowship [FL140100052]
- Monash Institute of Pharmaceutical Sciences
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While best known for its important signalling functions in human physiology, nitric oxide is also of considerable therapeutic interest. As such, nanoparticle-based systems which enable the sustained exogenous delivery of nitric oxide have been the subject of considerable investigation in recent years. Herein we review the various nanoparticle systems that have been used to date for nitric oxide delivery, and explore the array of potential therapeutic applications that have been reported. Specifically, we discuss the modification of sol-gel based silica particles, functionalised metal/metal oxide nanoparticles, polymer-coated metal nanoparticles, dendrimers, micelles and star polymers to impart nitric oxide release capability. We also consider the various areas in which therapeutic applications are envisaged: wound healing, antimicrobial applications, cardiovascular treatments, sexual medicine and cancer treatment. Finally, we discuss possible future directions for this versatile and potentially important technology. (C) 2015 Elsevier B.V. All rights reserved.
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