Journal
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Volume 48, Issue 4, Pages 291-296Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.bjoms.2009.06.007
Keywords
mTOR; CCR7; PI3K; Squamous cell carcinoma of head and neck; Survival
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Funding
- National Natural Science Foundation of China [30672331]
- Scientific Research Starting Foundation for Young Scholars of School of Stomatology, China Medical University [K101593-09-18]
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Metastatic squamous cell carcinoma (SCC) of the head and neck expresses chemokine receptor 7 (CCR7). which activates phosphoinositide-3 kinase (PI3K) to promote invasion and survival of SCC cells in the head and neck. We hypothesised that mammalian target of rapamycin (m-TOR) may be the downstream molecule of the CCR7-PI3K pathway. Results have shown that interaction between CCR7 and its ligand CCL19 induces the phosphorylation of mTOR and its target p70s6k. This phosphorylation is abolished by inhibition of CCR7 and PI3K/Akt, indicating that mTOR is involved in the CCR7-PI3K cascade. The inhibitors of mTOR and CCR7-PI3K also lead to a significant increase in CCL19-induced death, apoptosis, and cell-cycle arrest of metastatic SCC cells in the head and neck. Taken together, our data indicate the important part played by mTOR in CCR7-induced survival of such SCC cells. (C) 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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