Journal
JOURNAL OF CONTROLLED RELEASE
Volume 219, Issue -, Pages 548-559Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2015.08.039
Keywords
Nanoparticle; Drug delivery; Biological barriers; Blood-brain barrier; Tumor microenvironment; Vector-borne disease
Funding
- U.S. Army Medical Center and Materiel Command [W81-XWH-11-10700]
- Bill and Melinda Gates Foundation Grand Challenges Exploration [OPP 1087610]
- Iowa State Nanovaccine Initiative
- Vlasta Klima Balloun Professorship
- National Institutes of Health [NS 074443, 5R01 AG043540-02, P01DA028555, R01 NS36126, 2R01 NS034239, P30 MH062261]
- W. Eugene and Linda Lloyd Endowed Chair
- National Cancer Institute at the National Institutes of Health [P50 CA97274/UI, P30 CA086862]
- Lyle and Sharon Bighley Professorship
- Foundation for the National Institutes of Health through the Vector-based Transmission of Control: Discover Research program of the Grand Challenges in Global Health initiative
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Complex biological barriers are major obstacles for preventing and treating disease. Nanocarriers are designed to overcome such obstacles by enhancing drug delivery through physiochemical barriers and improving therapeutic indices. This review critically examines both biological barriers and nanocarrier payloads for a variety of drug delivery applications. A spectrum of nanocarriers is discussed that have been successfully developed for improving tissue penetration for preventing or treating a range of infectious, inflammatory, and degenerative diseases. (C) 2015 Elsevier B.V. All rights reserved.
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