Journal
APPLIED OPTICS
Volume 48, Issue 1, Pages 28-36Publisher
OPTICAL SOC AMER
DOI: 10.1364/AO.48.000028
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Funding
- Department of Trade and Industry Beacon project, the European Union (EU) Framework VI project [LSHG-CT-2003-503259]
- British Council programme: British-Italian Partnership
- Sixth Framework Programme of the EU [RII3-CT-2003-506350]
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We present an algorithm for simultaneous reconstruction of optical parameters, quantum yield, and life-time in turbid media with embedded fluorescent inclusions. This algorithm is designed in the Fourier domain as an iterative solution of a system of differential equations of the Helmholtz type and does not involve full ill-conditioned matrix computations. The approach is based on allowing the unknown optical parameters, quantum yield, and lifetime to depend on the Fourier spectral parameter. The algorithm was applied to a time-gated experimental data set acquired by imaging a highly scattering cylindrical phantom concealing small fluorescent tubes. Relatively accurate reconstruction demonstrates the potential of the method. (C) 2008 Optical Society of America
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