Journal
JOURNAL OF CONTROLLED RELEASE
Volume 199, Issue -, Pages 53-62Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2014.12.011
Keywords
Photothermal response system; In situ drug delivery; Combination therapy; Hyperthermia; Antibiotic therapy
Funding
- National Science Council of the Republic of China, Taiwan [NSC 101-2320-B-007-003-MY3]
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Eradicating subcutaneous bacterial infections remains a significant challenge. This work reports an injectable system of hollow microspheres (HMs) that can rapidly produce localized heat activated by near-infrared (NIR) light and control the release of an antibiotic via a molecular switch in their polymer shells, as a combination strategy for treating subcutaneous abscesses. The HMs have a shell of poly(D,L-lactic-co-glycolic acid) (PLGA) and an aqueous core that is comprised of vancomycin (Van) and polypyrrole nanoparticles (PPy NPs), which are photothermal agents. Experimental results demonstrate that the micro-HMs ensure efficiently the spatial stabilization of their encapsulated Van and PPy NPs at the injection site in mice with subcutaneous abscesses. Without NIR irradiation, the HMs elute a negligible drug concentration, but release substantially more when exposed to NIR light, suggesting that this system is suitable as a photothermally-responsive drug delivery system. The combination of photothermally-induced hyperthermia and antibiotic therapy with HMs increases cytotoxicity for bacteria in abscesses, to an extent that is greater than the sum of the two treatments alone, demonstrating a synergistic effect. This treatment platform may find other clinical applications, especially for localized hyperthermia-based cancer therapy. (C) 2014 Elsevier B.V. All rights reserved.
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