Journal
BRITISH JOURNAL OF NUTRITION
Volume 108, Issue 3, Pages 431-439Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114511005800
Keywords
Lycopene; Angiogenesis; TNF; Vascular endothelial growth factor; Human umbilical vein endothelial cells; Rat aortic rings
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Funding
- HJ Heinz Limited (Hayes, Middlesex, UK)
- Institute of Biomedical and Biomolecular Science (IBBS, Portsmouth, Hampshire, UK)
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Angiogenesis is important for tumour vascularisation and growth, and is therefore a promising target for cancer therapy. The present study reports inhibition of in vitro angiogenesis in human umbilical vein endothelial cells (HUVEC) as well as in rat aortic rings at physiological concentrations of lycopene, that is, 1-2 mu mol/l. At a final concentration of 1.15 mmol/l, a significant reduction (P < 0.05) in network branching, that is, junction numbers, the number of tubules and tubule length, was observed in both HUVEC as well as in the rat aortic rings. The inhibitory effect of lycopene was independent of the presence of the pro-angiogenic agents, vascular endothelial growth factor and TNF-alpha. The anti-angiogenic effects of lycopene in the present study were shown at a concentration that should be achievable by dietary means. These results extend our knowledge of one of the putative anti-cancer actions of lycopene.
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