Journal
BRITISH JOURNAL OF NUTRITION
Volume 104, Issue 6, Pages 803-806Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114510001327
Keywords
3-O-methylglucose; Sodium-dependent GLUT 1; GLUT 2; Glucagon-like peptide-1
Categories
Funding
- Sylvia and Charles Viertel Charitable Foundation
- Faculty of Health Sciences, University of Adelaide
- National Health and Medical Research Council of Australia
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It has been reported that the artificial sweetener, sucralose, stimulates glucose absorption in rodents by enhancing apical availability of the transporter GLUT2. We evaluated whether exposure of the proximal small intestine to sucralose affects glucose absorption and/or the glycaemic response to an intraduodenal (ID) glucose infusion in healthy human subjects. Ten healthy subjects were studied on two separate occasions in a single-blind, randomised order. Each subject received an ID infusion of sucralose (4mM in 0.9% saline) or control (0.9% saline) at 4 ml/min for 150 min (T = 230 to 120 min). After 30 min (T = 0), glucose (25%) and its non-metabolised analogue, 3-O-methylglucose (3-OMG; 2.5%), were co-infused intraduodenally (T = 0-120 min; 4.2 kJ/min (1 kcal/min)). Blood was sampled at frequent intervals. Blood glucose, plasma glucagon-like peptide-1 (GLP-1) and serum 3-OMG concentrations increased during ID glucose/3-OMG infusion (P<0.005 for each). However, there were no differences in blood glucose, plasma GLP-1 or serum 3-OMG concentrations between sucralose and control infusions. In conclusion, sucralose does not appear to modify the rate of glucose absorption or the glycaemic or incretin response to ID glucose infusion when given acutely in healthy human subjects.
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