Journal
BRITISH JOURNAL OF NUTRITION
Volume 101, Issue 11, Pages 1673-1678Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114508123418
Keywords
Panax ginseng; Glucose response; Insulin; Glycated Hb levels
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Funding
- Pharmaton SA, Lugano, Switzerland
- Korea Ginseng Corporation, Seoul, Korea
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In the absence of effective pharmacotherapy for diabetes there has been an increase in the use of, and research into, alternative treatment strategies. These include exercise, dietary interventions and the use of supplements including extracts of ginseng. Two separate, placebo-controlled, double-blind, cross-over studies investigating the effects of chronic ingestion of Panax ginseng (study I used G 115, study 2 used Cheong Kwan Jang) on glycated Hb (HbA1c: study 1, n 18; study 2, n 11), fasting plasma insulin (study 1, n 17; study 2, n 12), fasting plasma glucose and postprandial response (following breakfast) (study 1, n 23; study 2, n 14) in healthy volunteers are reported. I n both studies it was found that Panax ginseng had no effect on any gluco-regulatory parameter investigated. These results are not consistent with those reported for a diabetic sample (albeit using slightly different outcomes). These results would suggest that chronic use of Panax ginseng by non-diabetic individuals will have little long-term effect on glucose regulation. The benefits to glucose regulation associated with long-term ginseng use may only be present in populations with compromised glucose control; however, further research is needed to confirm such a speculation.
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