Journal
BRITISH JOURNAL OF NUTRITION
Volume 99, Issue -, Pages ES60-ES77Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114508965776
Keywords
Flavonoids; brain; cognitive function; neurodegeneration; cell signalling
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/C518222/1, BB/F008953/1]
- Medical Research Council [G0400278/NI02]
- European Co-operation in the field of Scientific and Technical (COST) Research Action [926]
- Biotechnology and Biological Sciences Research Council [BB/F008953/1, BB/C518222/1] Funding Source: researchfish
- Medical Research Council [G0400278] Funding Source: researchfish
- BBSRC [BB/F008953/1] Funding Source: UKRI
- MRC [G0400278] Funding Source: UKRI
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Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert beneficial effects on the central nervous system by protecting neurons against stress-induced injury, by suppressing neuroinflammation and by improving cognitive function. It is likely that flavonoids exert such effects, through selective actions on different components of a number of protein kinase and lipid kinase signalling cascades, such as the phosphatidyl-inositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase (MAPK) pathways. This review explores the potential inhibitory or stimulatory actions of flavonoids within these pathways, and describes how such interactions are likely to underlie neurological effects through their ability to affect the activation state of target molecules and/or by modulating gene expression. Future research directions are outlined in relation to the precise site(s) of action of flavonoids within signalling pathways and the sequence of events that allow them to regulate neuronal function.
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