Effect of Pentane-1,5-diol and Propane-1,2-diol on Percutaneous Absorption of Terbinafine

The aim of this study was to compare pentane-1,5-diol and propane-1,2-diol used as absorption enhancers for cutaneously administered terbinafine. Fresh human skin samples were placed in a continuous flow diffusion cell with a gel containing terbinafine on top of the skin. Receptor fluid samples were analysed using high-performance liquid chromatography. The quantity of gel remaining on the skin surface after completion of each test was weighed and the amount of drug in the skin was analysed. Addition of pentane-1,5-diol or propane-1,2-diol to the gel increased the percutaneous absorption of the drug. The most efficient absorption enhancer in this comparison was 5% pentane-1,5-diol. Key words: high-performance liquid chromatography; percutaneous absorption enhancer; pentane-1,5-diol; propane-1,2-diol; terbinafine.