Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Volume 297, Issue 4, Pages F849-F863Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00181.2009
Keywords
K(ir)1.1; KCNJ; inward-rectifying potassium channel; Bartter's syndrome; pseudohypoaldosteronism type II; serine- and glucocorticoid-regulated kinase-1; WNK kinase; phosphatidylinositol 4,5-bisphosphate
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [DK-54231, DK-63049]
- American Heart Association [GIA0855321E]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK063049, R01DK054231] Funding Source: NIH RePORTER
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Welling PA, Ho K. A comprehensive guide to the ROMK potassium channel: form and function in health and disease. Am J Physiol Renal Physiol 297: F849-F863, 2009. First published May 20, 2009; doi:10.1152/ajprenal.00181.2009.-The discovery of the renal outer medullary K+ channel (ROMK, K(ir)1.1), the founding member of the inward-rectifying K+ channel (K-ir) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. Here we provide a comprehensive guide to ROMK, spanning from the physiology in the kidney to the organization and regulation by intracellular factors to the structural basis of its function at the atomic level.
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