Journal
ARKIVOC
Volume -, Issue -, Pages 247-254Publisher
ARKAT USA INC
DOI: 10.3998/ark.5550190.0010.a22
Keywords
Telmisartan; antihypertensive drug; Suzuki coupling; oxazoline hydrolysis
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Funding
- SVNIT, Surat
- IICT, Hyderabad
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An improved, convergent and industrially useful process suitable for large-scale production of Telmisartan has been described. The key steps are Suzuki coupling for the preparation of key intermediate 2-[4'-(chloromethyl)biphenyl-2-yl]-4,4-dimethyl-4,5-dihydro-1,3-oxazole of Telmisartan, N-alkylation and oxazoline hydrolysis.
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