Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 157, Issue 6, Pages 742-746Publisher
WILEY
DOI: 10.1111/j.1365-2141.2012.09122.x
Keywords
autoimmune disease; blood and marrow transplantation; cell therapy; stem cell transplantation; stem cells
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The British Society of Blood and Marrow Transplantation Data Registry was used to analyse outcomes of haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases (SADs) from 1997 to 2009. 55 autologous and 15 allogeneic HSCT were registered (0.22% of overall UK HSCT activity). Sustained responses were observed following HSCT, although toxicity was significant. This is the first reported national analysis of long-term outcomes of HSCT in SADs, and should be viewed in the context of translational and developmental phases of HSCT in poor prognosis and refractory SADs. Treatment of poor-risk but reversible SADs with adequate fitness for HSCT in accordance with current guidelines is warranted.
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