Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 152, Issue 4, Pages 392-400Publisher
WILEY
DOI: 10.1111/j.1365-2141.2010.08561.x
Keywords
genetic manipulation; stem cell; polyethylene glycol; enzyme converted group O red blood cell; blood group systems
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P>In transfusion medicine, three major issues, i.e. heterogeneity of human blood groups, dependence of blood supply on donation, and shortage of some phenotypes, oblige clinicians to juggle with available biological material to avoid or limit post-transfusion reactions. This 'fact of life' has given impetus to a 30-year-old quest to achieve interchangeability of blood products between donors and recipients by eliminating blood group antigens.
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