Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 153, Issue 1, Pages 43-46Publisher
WILEY
DOI: 10.1111/j.1365-2141.2010.08457.x
Keywords
ABL1; FOXP1; SNX2; ALL; acute lymphoblastic leukaemia
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Funding
- Dr Mildred Scheel Stiftung fur Krebsforschung (Deutsche Krebshilfe e.V.)
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P>We have identified two novel ABL1 fusion genes in two patients with B-cell acute lymphoblastic leukaemia (ALL) associated with a t(3;9)(p12;q34) and a t(5;9)(q23;q34), respectively. Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9). The fusions were confirmed by specific amplification of the genomic breakpoints using reverse transcription polymerase chain reaction. The identification of ALL with rare ABL1 fusion partners is important because the leukaemia may respond to tyrosine kinase inhibitors in the same way as ALL patients with a classical BCR-ABL1 fusion gene.
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