Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 149, Issue 3, Pages 388-390Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2010.08110.x
Keywords
human papilloma virus; second primary malignancy; chronic lymphocytic leukaemia
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Funding
- D. Warren Brown Foundation
- Leukaemia and Lymphoma Society
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P>Second primary malignancies have long been associated with chronic lymphocytic leukaemia (CLL). We assessed secondary tumour samples from CLL and control patients for the presence of human papilloma virus (HPV). 132 CLL patients with 44 second malignancies were compared to a matched randomly-identified control population of 264 non-CLL patients with 54 solid malignancies. Polymerase chain reaction was performed with the highly conserved MY09/MY11 HPV primer. None of control samples were HPV-positive, while 53% of samples from the CLL group were positive. This report describes preliminary evidence for the presence of HPV in secondary malignancies, in patients with CLL.
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