Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 149, Issue 3, Pages 383-387Publisher
WILEY
DOI: 10.1111/j.1365-2141.2010.08098.x
Keywords
acute myeloid leukaemia; bax; bcl-2; FLT3-ITD; nucleophosmin gene; prognosis
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Funding
- Ministero dell'Universita e della Ricerca Scientifica e Tecnologica (MURST)
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P>Nucleophosmin gene (NPM1) mutations characterize acute myeloid leukaemia (AML) with normal karyotype and frequently co-exist with FLT3 internal tandem duplications (ITD). We evaluated bcl-2, bax, NPM1 and FLT3-ITD in 222 AML patients. Bax/bcl-2 ratio > 0 center dot 35 and NPM1 without FLT3-ITD were significantly associated (P = 0 center dot 0001). NPM1-mutated (mt)/FLT3-ITD negative patients showed a higher complete remission (CR) rate (90%, P = 0 center dot 0002) and a longer overall survival (OS, P = 0 center dot 00007). NPM1-mt/FLT3-ITD negative plus bax/bcl-2 > 0 center dot 35 subset showed a very high CR rate (96%), very long OS (P = 0 center dot 00005) and disease-free survival (P = 0 center dot 004). The favourable prognosis of NPM1-mt/FLT3-ITD negative patients might be explained by a higher bax/bcl-2 ratio.
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