Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 148, Issue 1, Pages 115-118Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1365-2141.2009.07945.x
Keywords
Hodgkin lymphoma; IRF4; MUM1; CD40; CD95; FAS; chemotherapy
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Funding
- Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.), Milan, Italy
- Ministero della Salute, Ricerca Finalizzata FSN, I.R.C.C.S., Rome, Italy
- Ministero della Salute, Rome
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P>The effects of proliferative, apoptotic and anti-proliferative stimuli on interferon regulatory factor 4 (IRF4) expression by Reed-Sternberg (RS) cells were analysed using a panel of Hodgkin lymphoma (HL)-derived cell lines. IRF4 expressed by HL cells was consistently upregulated after CD40 engagement; IRF4 was downregulated by agonistic anti-CD95 antibodies in the FAS-sensitive HDLM-2 cells and after treatment with Adriamycin and Dacarbazine, two chemotherapic agents commonly used for HL treatment. These results demonstrated, for the first time, that IRF4 was up-modulated by CD40 engagement, and down-modulated by apoptotic and anti-proliferative signals, suggesting an involvement of IRF4 also in HL pathobiology.
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