Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 141, Issue 5, Pages 672-675Publisher
WILEY
DOI: 10.1111/j.1365-2141.2008.07077.x
Keywords
microRNA; diffuse large B-cell lymphoma; lymphoma; sera; plasma
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Funding
- Cancer Research UK Funding Source: Medline
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Circulating nucleic acids have been shown to have potential as non-invasive diagnostic markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by comparing levels of tumour-associated MIRN155 (miR-155), MIRN210 (miR-210) and MIRN21 (miR-21) in serum from diffuse large B-cell lymphoma (DLBCL) patients (n = 60) with healthy controls (n = 43). Levels were higher in patient than control sera (P = 0.009, 0.02 and 0.04 respectively). Moreover, high MIRN21 expression was associated with relapse-free survival (P = 0.05). This is the first description of circulating microRNAs and suggests that microRNAs have potential as non-invasive diagnostic markers for DLBCL and possibly other cancers.
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