Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 142, Issue 5, Pages 827-830Publisher
WILEY
DOI: 10.1111/j.1365-2141.2008.07241.x
Keywords
fibroblast activation protein alpha; mesenchymal stromal cells; surface protein marker
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Mesenchymal stromal cells (MSCs) have gained widespread popularity in cell therapy, but their development into clinical products has been impeded by the scarcity of cell-specific markers. We previously explored transcriptome and membrane proteome of MSCs, from which fibroblast activation protein alpha (FAP) was recognized as a prime surface marker candidate. The present study showed that FAP was constitutively expressed on MSCs, but not on other cells. FAP immunoselection yielded homogeneous MSCs from cryopreserved bone marrow (BM). These results suggest that FAP serves as a surface protein marker that can singly define MSCs from BM and possibly from other sources.
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