Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 143, Issue 2, Pages 248-252Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2008.07329.x
Keywords
mantle cell lymphoma; sox11; nuclear expression; survival; proliferation
Categories
Funding
- Swedish Cancer Society
- Swedish Research Council
- Gunnar Nilsson Cancer Foundation
- Cancer Society in Stockholm
- Magnus Bergvall Foundation
- Karolinska Institutet Funds
- Stockholm County Council funds
Ask authors/readers for more resources
Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available