Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 143, Issue 1, Pages 3-15Publisher
WILEY
DOI: 10.1111/j.1365-2141.2008.07284.x
Keywords
NF-kappa B; lymphoma; leukaemia; apoptosis; inhibitor; proteasome
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Funding
- Cancer Research UK
- Tenovus
- Leukaemia Research Fund
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Nuclear Factor kappaB (NF-kappa B) transcription factors are central regulators of lymphocyte proliferation, survival and development. Although normally subject to tight control, constitutive activation of NF-kappa B promotes inappropriate lymphocyte survival and proliferation, and is recognised as key pathological feature in various lymphoid malignancies. Inhibition of NF-kappa B may be an attractive therapeutic approach in these diseases. This review focuses on the mechanisms and functional consequences of NF-kappa B activation in lymphoid malignancies and potential therapeutic strategies for inhibition of NF-kappa B.
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