Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 8, Issue 9, Pages 1309-1316Publisher
TAYLOR & FRANCIS INC
DOI: 10.1586/ERC.10.123
Keywords
antirheumatic therapy; atherosclerosis; cardiovascular risk factors; immune dysregulation; inflammation; rheumatoid arthritis
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Rheumatoid arthritis is a chronic inflammatory disease characterized by a reduced life expectancy mainly due to cardiovascular disease. In long-standing disease, it has been widely demonstrated that both traditional cardiovascular risk and disease-related factors, including chronic inflammation and immune-mediated mechanisms, play a key role in accelerating atherosclerotic damage of the arterial wall. The short- and long-term effects of immunosuppressive treatment on cardiovascular disease outcome is, however, uncertain and a multidisciplinary approach appears to represent the best management of cardiovascular risk in these patients.
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