Journal
ARKIVOC
Volume -, Issue -, Pages 209-246Publisher
ARKAT USA INC
DOI: 10.3998/ark.5550190.0011.105
Keywords
Gewald reaction; substituted 2-aminothiophenes; drug design; optoelectronics; dyes
Categories
Funding
- VEGA [1/0229/10, 1/0266/10, 1/0774/08, 1/0817/08, 1/1005/09]
- VVCE [0004-07]
- FaF [UK/16/2010]
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Chemistry of 2-aminothiophenes is arguably one of the most extensive and dynamic field of present-day thiophene research. Since 1961 when first report on the Gewald reaction was reported it became a universal method for synthesis of substituted 2-aminothiophenes and has gained prominence in recent times. The availability of reagents and the mild reaction conditions all contribute to the versatility of this reaction. This review summarizes the synthetic strategies for substituted 2-aminothiophenes. Consequently, details about the proposed mechanism of Gewald-like reactions and the wide scope of substituted 2-aminothiophenes for real life applications.
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