Journal
NATURE REVIEWS CANCER
Volume 10, Issue 10, Pages 720-728Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2915
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Funding
- Alex's Lemonade Stand Foundation
- US National Institute of Health [R01GM069905, R01CA150265, R01CA89455]
- NATIONAL CANCER INSTITUTE [R01CA089455, R01CA150265] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069905] Funding Source: NIH RePORTER
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The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation of the elongation stage of transcription could be fundamental to MLL-based leukaemogenesis. Recent studies have identified ELL complexed with several of the translocation partners of MLL in a transcriptional super elongation complex (SEC). These studies provide evidence for the importance of the regulation of Pol II elongation in disease pathogenesis and suggest that MLL chimaeras function by licensing Pol II transcription elongation without the appropriate checkpoints.
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