Journal
NATURE REVIEWS CANCER
Volume 10, Issue 10, Pages 669-682Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2931
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Funding
- NATIONAL CANCER INSTITUTE [R01CA127383] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA127383] Funding Source: Medline
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The discovery that cancer can be governed above and beyond the level of our DNA presents a new era for designing therapies that reverse the epigenetic state of a tumour cell. Understanding how altered chromatin dynamics leads to malignancy is essential for controlling tumour cells while sparing normal cells. Polycomb and trithorax group proteins are evolutionarily conserved and maintain chromatin in the 'off' or 'on' states, thereby preventing or promoting gene expression, respectively. Recent work highlights the dynamic interplay between these opposing classes of proteins, providing new avenues for understanding how these epigenetic regulators function in tumorigenesis.
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