Journal
AIDS AND BEHAVIOR
Volume 14, Issue 3, Pages 580-589Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10461-009-9615-1
Keywords
AIDS; Medication adherence; Antiretroviral medication; China; Electronic drug monitoring
Funding
- NCRR NIH HHS [K24 RR020300] Funding Source: Medline
- NIAID NIH HHS [K23 AI062208, P30 AI042853, K23 AI 62208] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [K24RR020300] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P30AI042853, K23AI062208] Funding Source: NIH RePORTER
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Effective antiretroviral therapy (ART) requires excellent adherence. Little is known about how to improve ART adherence in many HIV/AIDS-affected countries, including China. We therefore assessed an adherence intervention among HIV-positive patients in southwestern China. Eighty subjects were enrolled and monitored for 6 months. Sixty-eight remaining subjects were randomized to intervention/control arms. In months 7-12, intervention subjects were counseled using EDM feedback; controls continued with standard of care. Among randomized subjects, mean adherence and CD4 count were 86.8 vs. 83.8% and 297 vs. 357 cells/mu l in intervention vs. control subjects, respectively. At month 12, among 64 subjects who completed the trial, mean adherence had risen significantly among intervention subjects to 96.5% but remained unchanged in controls. Mean CD4 count rose by 90 cells/mu l and declined by 9 cells/mu l among intervention and control subjects, respectively. EDM feedback as a counseling tool appears promising for management of HIV and other chronic diseases.
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