Journal
NATURE REVIEWS CANCER
Volume 10, Issue 6, Pages 389-402Publisher
NATURE RESEARCH
DOI: 10.1038/nrc2867
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Funding
- National Institute of Health, NCI-CCR
- NATIONAL CANCER INSTITUTE [ZIABC005480] Funding Source: NIH RePORTER
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Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.
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