Journal
PHARMACEUTICALS
Volume 3, Issue 5, Pages 1456-1490Publisher
MDPI
DOI: 10.3390/ph3051456
Keywords
cell-penetrating peptides (CPPs); targeted drug delivery; homing peptides; selective targeting; peptide transduction domains (PTDs)
Categories
Funding
- MCI-FEDER [Bio2008-00799]
- Generalitat de Catalunya (XRB)
- Generalitat de Catalunya [2009SGR-1005]
- CONSOLIDER-INGENIO 2010
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There is a pressing need for more effective and selective therapies for cancer and other diseases. Consequently, much effort is being devoted to the development of alternative experimental approaches based on selective systems, which are designed to be specifically directed against target cells. In addition, a large number of highly potent therapeutic molecules are being discovered. However, they do not reach clinical trials because of their low delivery, poor specificity or their incapacity to bypass the plasma membrane. Cell-penetrating peptides (CPPs) are an open door for cell-impermeable compounds to reach intracellular targets. Putting all these together, research is sailing in the direction of the design of systems with the capacity to transport new drugs into a target cell. Some CPPs show cell type specificity while others require modifications or form part of more sophisticated drug delivery systems. In this review article we summarize several strategies for directed drug delivery involving CPPs that have been reported in the literature.
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