Journal
NATURE REVIEWS CANCER
Volume 10, Issue 1, Pages 51-57Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2772
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Funding
- Spanish National Cancer Research Centre
- Spanish Ministry of Science
- Regional Government of Madrid
- European Union (PROTEOMAGE)
- European Research Council
- Marcelino Botin Foundation
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The importance of cellular senescence, which is a stress response that stably blocks proliferation, is increasingly being recognized. Senescence is prevalent in pre-malignant tumours, and progression to malignancy requires evading senescence. Malignant tumours, however, may still undergo senescence owing to interventions that restore tumour suppressor function or inactivate oncogenes. Senescent tumour cells can be cleared by immune cells, which may result in efficient tumour regression. Standard chemotherapy also has the potential to induce senescence, which may partly underlie its therapeutic activity. Although these concepts are well supported in mouse models, translating them to clinical oncology remains a challenge.
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