Journal
NATURE REVIEWS CANCER
Volume 10, Issue 1, Pages 65-76Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2681
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Funding
- US National Cancer Institute (NCI) [CA099961, CA051995, CA117927]
- Roemmers Foundation
- Harry J Lloyd Charitable Trust
- ANPCyT [PICT-2007-01010]
- NCI [T32 CA121929]
- American Cancer Society (ACS), Illinois Division [PF-09-112-01-GMC]
- NATIONAL CANCER INSTITUTE [R01CA051995, R29CA051995, R01CA117927, R01CA099961, R01CA059908] Funding Source: NIH RePORTER
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Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.
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