Journal
BRITISH JOURNAL OF DERMATOLOGY
Volume 169, Issue 2, Pages 406-411Publisher
WILEY
DOI: 10.1111/bjd.12313
Keywords
-
Categories
Funding
- U.S. National Institutes of Health [R01AR042742, R01AR050511]
- Higher Education Commission of Pakistan
- Ann Arbor Veterans Affairs Hospital
Ask authors/readers for more resources
Background Genetic predisposition to psoriasis, an inflammatory skin disease affecting 02-4% of the world population, is well established. Thus far, 41 psoriasis susceptibility loci reach genome-wide significance (P5x10(-8)). Identification of genetic susceptibility loci in diverse populations will help understand the underlying biology of psoriasis susceptibility. Objectives The primary objective of this study was to examine psoriasis susceptibility associations previously reported in Chinese and caucasian populations in a Pakistani cohort. Methods Blood samples and phenotype data were collected from psoriasis cases and controls in Islamabad, Pakistan. DNA was isolated and genotypes of selected susceptibility markers were determined. The data were analysed using (2) tests or logistic regression for psoriasis association. Results HLA-Cw6 showed the strongest association [odds ratio (OR) 243, P=23x10(-12)]. HLA-Cw1 showed marginally significant association (OR 166, P=0049), suggesting that the HLA-Cw1-B46 risk haplotype may be present in the Pakistani population. Three other loci (IL4/IL13, NOS2, TRAF3IP2) showed nominally significant association (P<005). Conclusions HLA-Cw6 is strongly associated with psoriasis susceptibility in the Pakistani population, as has been found in every other population studied. In addition, HLA-Cw1 showed marginal association, reflecting the relative geographical proximity and thus likely genetic relatedness to other populations in which the HLA-Cw1-B46 haplotype is known to be associated. A larger cohort and a denser marker set will be required for further analysis of psoriasis associations in the South Asian population.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available